Actor Johnny Depp was born John Christopher Depp II, in Owensboro, Kentucky, on June 9, 1963, to parents John and Betty Sue Depp. Depp's father worked as a civil engineer, and his mother came from full-blooded Cherokee stock, and worked as a waitress and homemaker. The youngest of four children, Depp was withdrawn and a self-admitted oddball. "I made odd noises as a child," he later revealed in an interview. "Just did weird things, like turn off light switches twice. I think my parents thought I had Tourette's syndrome."

Johnny and his family moved frequently to accommodate his father's job, finally landing in Miramar, Florida, when Johnny was 7 years old. The family lived in a motel for nearly a year, until his father found a job. Depp hated his new home and, by the age of 12 began smoking, experimenting with drugs, and engaging in self-harm due to the stress of family problems. "Puberty was very vague," he has said. "I literally locked myself in a room and played guitar."

In 1978, when Depp was 15, his parents got divorced. As the youngest of four, it became Johnny's job to go to his father's office and pick up the weekly child-support money. The split caused a rift between Johnny and his father. At 16, Depp dropped out of high school and joined the garage band, The Kids. The group became successful enough to open for the Talking Heads and the B-52s, but they barely made ends meet. Depp lived for months in a friend's '67 Chevy Impala.

On December 24, 1983, Depp married Lori Anne Allison, the sister of his band's bass player and singer. During Depp's marriage, his wife worked as a makeup artist, while he worked a variety of odd jobs, including a telemarketer for pens. His wife introduced him to actor Nicolas Cage, who advised Depp to pursue an acting career. Depp and his wife divorced in 1985. Both Depp and his subsequent fiancé Sherilyn Fenn auditioned for the 1986 film Thrashin'. They were both cast, with Depp being chosen by the film's director to star as the lead, which would have been Depp's second major role. Depp was later turned down by the film's producer, who rejected the director's decision.